Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 19/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176197 | 0.86 | NAMPT (0.58) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL176170 | 0.86 | NAMPT (0.59) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16108136 | 0.86 | NAMPT (0.68) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16108269 | 0.73 | NAMPT (0.75) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL16107751 | 0.72 | NAMPT (0.72) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12466836 | 0.72 | NAMPT (0.85) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12467881 | 0.72 | NAMPT (0.76) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL173615 | 0.71 | NAMPT (0.69) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15531310 | 0.71 | NAMPT (0.69) | NAMPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5419581 | 0.71 | ROCK2 (0.62) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |