Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15780068 | 0.89 | DNM1 (0.51) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15075280 | 0.89 | DNM1 (0.50) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17634939 | 0.87 | TSHR (0.44) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL25751510 | 0.83 | MEN1 (0.71) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16384405 | 0.81 | MEN1 (0.68) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14493625 | 0.80 | MEN1 (0.55) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17371401 | 0.80 | TSHR (0.45) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13498474 | 0.79 | TSHR (0.44) | DNM1TSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22026449 | 0.79 | MEN1 (0.53) | TSHRMEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL25816699 | 0.79 | MEN1 (0.53) | DNM1TSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296737-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-29 | — | — | US | disclosed |