Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | RARG | P13631 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 6/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14159842 | 0.90 | RARB (0.47) | RARARARBRARGRXRARXRB | |
| Palovarotene SCHEMBL29354070 | 0.90 | RARB (0.57) | RARARARBRARGRXRARXRB | |
| Palovarotene SCHEMBL4658931 | 0.90 | RARB (0.57) | RARARARBRARGRXRARXRB | |
| Palovarotene SCHEMBL4668028 | 0.90 | RARB (0.57) | RARARARBRARGRXRARXRB | |
| SCHEMBL14159856 | 0.89 | RARA (0.46) | RARARARBRARGRXRARXRB | |
| SCHEMBL4666954 | 0.87 | RARA (0.44) | RARARARBRARGRXRARXRB | |
| SCHEMBL14159839 | 0.86 | RARB (0.44) | RARARARBRARGRXRARXRB | |
| SCHEMBL14159872 | 0.85 | RARA (0.42) | RARARARBRARGRXRARXRB | |
| SCHEMBL14376644 | 0.84 | RARA (0.41) | RARARARBRARGRXRARXRB | |
| SCHEMBL4666953 | 0.83 | RARA (0.48) | RARARARBRARGRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3000466-A1 | INHIBITOR FOR RETINOCHOROIDAL DISORDERS | Yamaguchi University (JP) | 2016-03-30 | — | — | EP | disclosed |