Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.79 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897827 | 0.90 | ALK (0.80) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL1755790 | 0.90 | ALK (0.80) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL897567 | 0.88 | ALK (1.00) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL21443121 | 0.86 | ALK (0.75) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL7812343 | 0.82 | ALK (0.69) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL897828 | 0.82 | ALK (0.72) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL897024 | 0.81 | ALK (0.87) | ALKKDRINSRABL1IGF1R | |
| SCHEMBL898081 | 0.80 | ALK (0.80) | ALK | |
| SCHEMBL17448470 | 0.80 | ALK (0.84) | ALK | |
| SCHEMBL20004119 | 0.79 | ALK (0.65) | ALKKDRINSRABL1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-B1 | TETRACYCLIC COMPOUND | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2016-03-30 | — | — | EP | disclosed |