Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21443121 | 0.93 | ALK (0.75) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL7812343 | 0.88 | ALK (0.69) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL897828 | 0.88 | ALK (0.72) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL897024 | 0.85 | ALK (0.87) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL1755790 | 0.80 | ALK (0.80) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL897827 | 0.80 | ALK (0.80) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL20004478 | 0.80 | ALK (0.56) | ALK | |
| SCHEMBL17636142 | 0.79 | ALK (0.79) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL897567 | 0.79 | ALK (1.00) | ALKKDRABL1INSRIGF1R | |
| SCHEMBL20004556 | 0.78 | ALK (0.66) | ALKKDRIGF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2975024-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2018-03-28 | — | — | EP | disclosed |