Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448223 | 0.91 | ELANE (0.70) | ELANECYP2C9 | |
| SCHEMBL4461711 | 0.90 | ELANE (0.68) | ELANECYP2C9 | |
| SCHEMBL1764354 | 0.88 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL3482734 | 0.88 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14899930 | 0.85 | ELANE (0.70) | ELANECYP2C9 | |
| SCHEMBL1134160 | 0.83 | ELANE (0.83) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872750 | 0.83 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL12593580 | 0.82 | ELANE (0.71) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1134183 | 0.82 | ELANE (0.71) | ELANECYP2C9CYP3A4 | |
| SCHEMBL14899953 | 0.81 | ELANE (0.90) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118221-A1 | 1,4-DIARYL-PYRIMIDOPYRIDAZINE-2,5-DIONES AND THEIR USE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118221-A1 | 1,4-DIARYL-PYRIMIDOPYRIDAZINE-2,5-DIONES AND THEIR USE | QDPR, DPYD, DPP4 | ELANE 1816/4885CYP2C9 1333/4885CYP3A4 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.