Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628533 | 0.88 | KMT2A (0.41) | MAPTPOLBLMNAGAAPTGS1 | |
| SCHEMBL17644101 | 0.83 | SLC6A2 (0.39) | MAPTLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20971986 | 0.80 | KMT2A (0.36) | MAPTPOLBLMNAGAAPTGS1 | |
| SCHEMBL20971892 | 0.79 | MAPT (0.38) | MAPTPOLBLMNAGAAPTGS1 | |
| SCHEMBL13002585 | 0.79 | ADAM10 (0.42) | NPC1RAB9AKDM4EMEN1MAPK1 | |
| SCHEMBL30632525 | 0.77 | SLC6A2 (0.36) | MAPTLMNASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL29374814 | 0.76 | GAA (0.45) | GAANPC1RAB9AALDH1A1 | |
| SCHEMBL17628534 | 0.76 | GAA (0.45) | GAANPC1RAB9AALDH1A1 | |
| SCHEMBL29766172 | 0.74 | MAPT (0.38) | MAPTPOLBGAANPC1RAB9A | |
| SCHEMBL24203568 | 0.69 | TSHR (0.41) | MAPTPOLBSMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072668-A1 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS | CHEMOCENTRYX, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9745268-B2 | Processes and intermediates in the preparation of C5aR antagonists | CHEMOCENTRYX, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160090357-A1 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS | CHEMOCENTRYX, INC. | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072668-A1 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | MAPT 4617/4885POLB 2356/4885LMNA 1860/4885 |
| US-20160090357-A1 | PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | MAPT 4617/4885POLB 2356/4885LMNA 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.