Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.57 |
| ▸ | INSR | P06213 | 5/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644558 | 0.99 | LRRK2 (0.58) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL17644542 | 0.98 | LRRK2 (0.60) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL17644539 | 0.93 | LRRK2 (0.58) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL17644586 | 0.91 | LRRK2 (0.61) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL17644540 | 0.89 | LRRK2 (0.59) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL17644552 | 0.88 | ALK (0.49) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL17644592 | 0.88 | LRRK2 (0.56) | LRRK2INSRALKEGFRIGF1R | |
| SCHEMBL17644553 | 0.86 | LRRK2 (0.56) | LRRK2INSRALKZAP70EGFR | |
| SCHEMBL20537247 | 0.86 | LRRK2 (0.54) | LRRK2INSRALKEGFRIGF1R | |
| SCHEMBL17644550 | 0.85 | LRRK2 (0.60) | LRRK2INSRALKZAP70EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576541-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | claimed |