Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644592 | 0.98 | LRRK2 (0.56) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644522 | 0.92 | LRRK2 (0.63) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644593 | 0.91 | TNK2 (0.65) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644583 | 0.90 | LRRK2 (0.60) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644542 | 0.89 | LRRK2 (0.60) | LRRK2ALKEGFRINSRIGF1R | |
| SCHEMBL17644564 | 0.89 | LRRK2 (0.51) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644537 | 0.88 | LRRK2 (0.59) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644512 | 0.88 | LRRK2 (0.59) | LRRK2ALKJAK2SRCTNK2 | |
| SCHEMBL17644540 | 0.88 | LRRK2 (0.59) | LRRK2 | |
| SCHEMBL17644518 | 0.87 | LRRK2 (0.53) | LRRK2ALKJAK2SRCTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576541-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | claimed |