Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 9/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | ROS1 | P08922 | 3/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644553 | 0.91 | LRRK2 (0.56) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL17644592 | 0.91 | LRRK2 (0.56) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL17644522 | 0.88 | LRRK2 (0.63) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644564 | 0.87 | LRRK2 (0.51) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644583 | 0.87 | LRRK2 (0.60) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644512 | 0.87 | LRRK2 (0.59) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644537 | 0.87 | LRRK2 (0.59) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644540 | 0.86 | LRRK2 (0.59) | LRRK2 | |
| SCHEMBL17644518 | 0.86 | LRRK2 (0.53) | TNK2ALKJAK2SRCLRRK2 | |
| SCHEMBL17644590 | 0.86 | ALK (0.47) | TNK2ALKJAK2SRCLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576541-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | claimed |