Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 6/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.59 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.59 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.59 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 6/20 | 0.32 |
| ▸ | FLT3 | P36888 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 2/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.31 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17644788 | 0.90 | IL2 (0.47) | IL2TNFSTIM1ORAI1PSMB8 | |
| SCHEMBL15205281 | 0.84 | IL2 (0.67) | IL2TNFSTIM1ORAI1LMNA | |
| SCHEMBL17644786 | 0.84 | IL2 (0.47) | IL2TNFSTIM1ORAI1PSMB8 | |
| SCHEMBL17644782 | 0.83 | IL2 (0.47) | IL2TNFSTIM1ORAI1PSMB8 | |
| SCHEMBL17644785 | 0.81 | IL2 (0.46) | IL2TNFSTIM1ORAI1PSMB8 | |
| SCHEMBL15205168 | 0.74 | IL2 (1.00) | IL2TNFSTIM1ORAI1MAPT | |
| SCHEMBL2732110 | 0.74 | IL2 (0.54) | IL2TNFSTIM1ORAI1LMNA | |
| SCHEMBL17656135 | 0.73 | IL2 (0.66) | IL2TNFSTIM1ORAI1NOTUM | |
| SCHEMBL2732589 | 0.71 | IL2 (1.00) | IL2TNFSTIM1ORAI1NPC1 | |
| SCHEMBL2787427 | 0.69 | STIM1 (0.48) | STIM1ORAI1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632906-B1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2016-04-06 | — | — | EP | claimed |