Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LCLAT1 | Q6UWP7 | 2/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | CPT2 | P23786 | 1/20 | 0.30 |
| ▸ | CPT1A | P50416 | 1/20 | 0.30 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733507 | 0.87 | IL2 (0.51) | IL2TNFSTIM1ORAI1MAPK14 | |
| SCHEMBL17644786 | 0.86 | IL2 (0.47) | IL2TNFSTIM1ORAI1NOTUM | |
| SCHEMBL17644782 | 0.85 | IL2 (0.47) | IL2TNFSTIM1ORAI1RAB9A | |
| SCHEMBL17644787 | 0.81 | IL2 (0.59) | IL2TNFSTIM1ORAI1RAB9A | |
| SCHEMBL17644788 | 0.78 | IL2 (0.47) | IL2TNFSTIM1ORAI1RAB9A | |
| SCHEMBL15205243 | 0.77 | IL2 (0.74) | IL2TNFSTIM1ORAI1LCLAT1 | |
| SCHEMBL15205186 | 0.71 | IL2 (0.54) | IL2TNFSTIM1ORAI1NOTUM | |
| SCHEMBL2787427 | 0.71 | STIM1 (0.48) | STIM1ORAI1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15205055 | 0.71 | IL2 (0.53) | IL2TNFSTIM1ORAI1MAPK14 | |
| SCHEMBL2785129 | 0.69 | MAPT (0.41) | RAB9AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632906-B1 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | LUPIN LTD (IN) | 2016-04-06 | — | — | EP | claimed |