Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542477 | 0.94 | CYP3A4 (0.59) | CYP3A4ABL1MAPK14MAPK10PIK3CD | |
| SCHEMBL1542369 | 0.83 | CYP3A4 (0.65) | CYP3A4ABL1MAPK14MAPK10CDK9 | |
| SCHEMBL1542876 | 0.81 | CYP3A4 (0.58) | CYP3A4MAPK14TRPV1MEN1KMT2A | |
| SCHEMBL1542928 | 0.80 | CYP3A4 (0.44) | CYP3A4ABL1CDC25ACDC25BMEN1 | |
| SCHEMBL2129460 | 0.80 | CYP3A4 (0.59) | CYP3A4ABL1MAPK14MAPK10TRPV1 | |
| SCHEMBL2127612 | 0.79 | CYP3A4 (0.58) | CYP3A4ABL1MAPK14TRPV1MEN1 | |
| SCHEMBL2128872 | 0.79 | CYP3A4 (0.57) | CYP3A4ABL1MAPK14TRPV1MEN1 | |
| SCHEMBL1542597 | 0.79 | CYP3A4 (0.57) | CYP3A4MAPK14TRPV1MEN1KMT2A | |
| SCHEMBL1542475 | 0.78 | CYP3A4 (0.56) | CYP3A4MAPK14MEN1KMT2A | |
| SCHEMBL2128420 | 0.77 | CYP3A4 (0.53) | CYP3A4MAPK14LYNMAPK9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110123489-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC (US) | 2011-05-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110123489-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HCCS, EIF2AK2, RNASE1 | CYP3A4 60/4885ABL1 375/4885MAPK14 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.