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SCHEMBL1764879

SCHEMBL1764879

O=C1CN(C(=O)c2cc(-c3cc(F)cc(OCCCl)c3)n(-c3ccc(F)c(Cl)c3)n2)CN1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.40
▸ KMT2A Q03164 3/20 0.40
▸ MAPT P10636 2/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ MALT1 Q9UDY8 2/20 0.38
▸ MGLL Q99685 4/20 0.38
▸ SLC5A1 P13866 7/20 0.38
▸ CHRNA7 P36544 1/20 0.36
▸ CCKAR P32238 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ RPA1 P27694 1/20 0.35
▸ KDM1A O60341 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12597297 0.94 MEN1 (0.40) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1765001 0.90 KCNH2 (0.43) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1764936 0.90 RPA1 (0.44) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1526038 0.87 MEN1 (0.45) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL29397883 0.87 MEN1 (0.45) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1765424 0.86 MEN1 (0.44) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1764881 0.86 CCKAR (0.43) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1764920 0.85 MEN1 (0.43) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1765015 0.84 MEN1 (0.50) MEN1KMT2AMAPTSMN1; SMN2NPSR1
SCHEMBL1765282 0.84 MEN1 (0.42) MEN1KMT2AMAPTSMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-8399682-B2 Substituted (pyrazolylcarbonyl)imidazolidinones and their use AICURIS GMBH & CO. KG (DE) 2013-03-19 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE AICURIS GMBH & CO. KG (DE) 2011-05-26 — — US disclosed
WO-2009115213-A1 (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES AICURIS GMBH & CO. KG (DE) 2009-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124618-A1 SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE TPMT, PAICS, THPO MEN1 2360/4885KMT2A 1193/4885MAPT 2876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.