Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653150 | 0.93 | AAK1 (0.49) | KDM4EAAK1PDE3BPDE3AMEN1 | |
| SCHEMBL17653084 | 0.88 | KDM4E (0.44) | KDM4EAAK1PDE3BPDE3AMEN1 | |
| SCHEMBL17653196 | 0.87 | AAK1 (0.39) | KDM4EAAK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17653107 | 0.85 | KDM4E (0.41) | KDM4EAAK1PDE3BPDE3AMEN1 | |
| SCHEMBL17653349 | 0.84 | AAK1 (0.45) | KDM4EAAK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17653110 | 0.82 | IMPDH2 (0.46) | KDM4EAAK1 | |
| SCHEMBL17653141 | 0.82 | AAK1 (0.38) | KDM4EAAK1PDE3BPDE3AMEN1 | |
| SCHEMBL17653266 | 0.82 | AAK1 (0.46) | KDM4EAAK1MMP13 | |
| SCHEMBL17663478 | 0.75 | AAK1 (0.69) | AAK1MEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL17653187 | 0.75 | AAK1 (0.46) | KDM4EAAK1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |