Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 6/20 | 0.47 |
| ▸ | CTSB | P07858 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17663451 | 1.00 | CTSK (0.49) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17663461 | 0.93 | CTSK (0.48) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17653416 | 0.86 | AAK1 (0.48) | AAK1 | |
| SCHEMBL17663453 | 0.85 | AAK1 (0.49) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17653258 | 0.85 | AAK1 (0.49) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17653101 | 0.79 | AAK1 (0.47) | AAK1 | |
| SCHEMBL19253006 | 0.78 | AAK1 (0.48) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17663452 | 0.78 | AAK1 (0.48) | CTSKAAK1CTSLCTSBCTSS | |
| SCHEMBL17653321 | 0.75 | AAK1 (0.48) | AAK1 | |
| SCHEMBL17653400 | 0.74 | AAK1 (0.49) | CTSKAAK1CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |