Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17654671 | 1.00 | GRIN2B (0.41) | GRIN2BTAAR1NR3C2MAOBDAO | |
| SCHEMBL23864963 | 0.88 | SMN1; SMN2 (0.36) | GRIN2BTAAR1NR3C2AOC3 | |
| SCHEMBL22483294 | 0.88 | GRIN2B (0.43) | GRIN2BTAAR1NR3C2MAOBDAO | |
| SCHEMBL17654604 | 0.86 | GAA (0.41) | GRIN2B | |
| SCHEMBL17654601 | 0.86 | GAA (0.41) | GRIN2B | |
| SCHEMBL17654417 | 0.85 | EPHX2 (0.46) | GRIN2B | |
| SCHEMBL17654416 | 0.85 | EPHX2 (0.46) | GRIN2B | |
| SCHEMBL19430923 | 0.84 | IDO1 (0.44) | GRIN2BTAAR1NR3C2MAOBDAO | |
| SCHEMBL23865024 | 0.80 | RXRA (0.46) | GRIN2BTAAR1MAOB | |
| SCHEMBL23864977 | 0.79 | RXRA (0.46) | GRIN2BTAAR1NR3C2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12234229-B2 | Sphingosine kinase inhibitor amidoxime prodrugs | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2025-02-25 | — | — | US | disclosed |
| US-20230050649-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2023-02-16 | — | — | US | disclosed |
| US-11180489-B2 | Sphingosine kinase inhibitor amidoxime prodrugs | U niversity of Virginia Patent Foundation (US) | 2021-11-23 | — | — | US | disclosed |
| EP-3436451-B1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | UNIV VIRGINIA PATENT FOUNDATION (US) | 2021-09-29 | — | — | EP | disclosed |
| EP-3201181-B1 | SPHINGOSINE KINASE INHIBITORS | VIRGINIA TECH INTELLECTUAL PROPERTIES INC (US) | 2020-12-02 | — | — | EP | disclosed |
| US-20200308159-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | SPHYNKX THERAPEUTICS, LLC | 2020-10-01 | — | — | US | disclosed |
| EP-3436451-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | University Of Virginia Patent Foundation (US) | 2019-02-06 | — | — | EP | disclosed |
| US-10100022-B2 | Sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-10-16 | — | — | US | disclosed |
| US-20170298032-A1 | SPHINGOSINE KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-19 | — | — | US | disclosed |
| US-20170298032-A1 | SPHINGOSINE KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-19 | — | — | US | disclosed |
| US-20170298032-A1 | SPHINGOSINE KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-10-19 | — | — | US | disclosed |
| WO-2017172989-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | THORPE STEVEN BRANDON (US) | 2017-10-05 | — | — | WO | disclosed |
| EP-3201181-A1 | SPHINGOSINE KINASE INHIBITORS | Virginia Tech Intellectual Properties, Inc. (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016054261-A1 | SPHINGOSINE KINASE INHIBITORS | LYNCH KEVIN (US) | 2016-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12234229-B2 | Sphingosine kinase inhibitor amidoxime prodrugs | SPHK1, SPHK2, S1PR2 | GRIN2B 3342/4885TAAR1 1734/4885NR3C2 3361/4885 |
| US-20200308159-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | SPHK1, SPHK2, S1PR2 | GRIN2B 3342/4885TAAR1 1734/4885NR3C2 3361/4885 |
| US-10100022-B2 | Sphingosine kinase inhibitors | SPHK1, SPHK2, S1PR2 | GRIN2B 4310/4885TAAR1 2233/4885NR3C2 1221/4885 |
| US-20230050649-A1 | SPHINGOSINE KINASE INHIBITOR AMIDOXIME PRODRUGS | SPHK1, SPHK2, S1PR2 | GRIN2B 3342/4885TAAR1 1734/4885NR3C2 3361/4885 |
| US-20170298032-A1 | SPHINGOSINE KINASE INHIBITORS | SPHK1, SPHK2, S1PR2 | GRIN2B 4310/4885TAAR1 2233/4885NR3C2 1221/4885 |
| US-11180489-B2 | Sphingosine kinase inhibitor amidoxime prodrugs | SPHK1, SPHK2, S1PR2 | GRIN2B 3342/4885TAAR1 1734/4885NR3C2 3361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.