⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765634 | 1.00 | — | — | |
| SCHEMBL1765471 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2232227 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL2239793 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL2232225 | 0.97 | — | — | |
| SCHEMBL23792888 | 0.82 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL1555156 | 0.80 | — | — | |
| SCHEMBL7741435 | 0.80 | — | — | |
| SCHEMBL1556637 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL1094574 | 0.78 | GABRR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50634-E1 | Diaryl macrocycles as modulators of protein kinases | Turning Point Therapeutics, Inc. (US) | 2025-10-14 | — | — | US | disclosed |
| US-12404281-B2 | Diaryl macrocycles as modulators of protein kinases | Turning Point Therapeutics, Inc. (US) | 2025-09-02 | — | — | US | disclosed |
| WO-2025111492-A1 | INHIBITORS OF PARG | 858 THERAPEUTICS, INC. (US) | 2025-05-30 | — | — | WO | disclosed |
| CN-115515685-B | EIF4E inhibitors and uses thereof | 皮克医疗公司 | 2025-04-08 | — | — | CN | disclosed |
| US-12157731-B2 | EIF4E inhibitors and uses thereof | PIC Therapeutics, Inc. (US) | 2024-12-03 | — | — | US | disclosed |
| CN-118307534-A | LTA4H inhibitors and uses thereof | 上海海雁医药科技有限公司 | 2024-07-09 | — | — | CN | disclosed |
| CN-115466251-B | Condensed heterocyclic compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | disclosed |
| US-20240140964-A1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-05-02 | — | — | US | disclosed |
| EP-4338739-A2 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | Turning Point Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| EP-3636649-B1 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TURNING POINT THERAPEUTICS INC (US) | 2024-02-14 | — | — | EP | disclosed |
| EP-0703909-A1 | $g(D)?6,7 -TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA & UPJOHN COMPANY (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0674630-A1 | 7-HALO- AND 7$g(b),8$g(b)-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA & UPJOHN COMPANY (US) | 1995-10-04 | — | — | EP | disclosed |
| EP-0528997-B1 | DISULFIDE DERIVATIVES OF MERCAPTOACYLAMINO ACIDS | SCHERING CORP (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994029288-A1 | Δ6,7-TAXOLS ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE UPJOHN COMPANY (US) | 1994-12-22 | — | — | WO | disclosed |
| WO-1994013655-A1 | 7-HALO- AND 7β,8β-METHANO-TAXOLS, ANTINEOPLASTIC USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | THE UPJOHN COMPANY (US) | 1994-06-23 | — | — | WO | disclosed |
| US-5219886-A | Cardiovascular disorders, analgesics, enzyme inhibitors | SCHERING CORPORATION (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0393441-B1 | MERCAPTO-ACYLAMINO ACIDS | SCHERING CORPORATION (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0467957-A1 | MERCAPTO-ACYLAMINO ACIDS | SCHERING CORPORATION (US) | 1992-01-29 | — | — | EP | disclosed |
| EP-0393441-A1 | Mercapto-acylamino acids | SCHERING CORPORATION (US) | 1990-10-24 | — | — | EP | disclosed |
| WO-1990012003-A1 | MERCAPTO-ACYLAMINO ACIDS | SCHERING CORPORATION (US) | 1990-10-18 | — | — | WO | disclosed |