Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 8/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 10/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12654660 | 0.90 | FGFR4 (0.46) | PHGDHFGFR4ADORA2A | |
| SCHEMBL12654516 | 0.89 | P2RX1 (0.48) | FGFR4ADORA2AP2RX1 | |
| SCHEMBL12654638 | 0.88 | FGFR4 (0.45) | PHGDHFGFR4 | |
| SCHEMBL17655343 | 0.86 | FGFR4 (0.46) | PHGDHFGFR4 | |
| SCHEMBL16775820 | 0.85 | PHGDH (0.47) | PHGDHADORA2A | |
| SCHEMBL12654399 | 0.85 | FGFR4 (0.59) | PHGDHFGFR4P2RX1 | |
| SCHEMBL16775837 | 0.85 | PHGDH (0.46) | PHGDHADORA2A | |
| SCHEMBL12654517 | 0.84 | FGFR4 (0.43) | FGFR4P2RX1 | |
| SCHEMBL12959008 | 0.84 | PHGDH (0.49) | PHGDHADORA2A | |
| SCHEMBL12654639 | 0.84 | FGFR4 (0.49) | FGFR4P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |