Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 11/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655327 | 0.90 | PHGDH (0.49) | FGFR4ADORA2APHGDH | |
| SCHEMBL12654527 | 0.88 | FGFR4 (0.56) | FGFR4PHGDH | |
| SCHEMBL17655345 | 0.86 | GRM5 (0.48) | FGFR4RAB9A | |
| SCHEMBL12654516 | 0.86 | P2RX1 (0.48) | FGFR4ADORA2ASORT1 | |
| SCHEMBL12654531 | 0.85 | FGFR4 (0.44) | FGFR4 | |
| SCHEMBL12654399 | 0.85 | FGFR4 (0.59) | FGFR4PHGDH | |
| SCHEMBL12654666 | 0.84 | FGFR4 (0.49) | FGFR4 | |
| SCHEMBL12654661 | 0.84 | FGFR4 (0.55) | FGFR4 | |
| SCHEMBL12654530 | 0.84 | CA2 (0.44) | FGFR4PHGDH | |
| SCHEMBL12654517 | 0.83 | FGFR4 (0.43) | FGFR4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |