Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 12/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12805953 | 0.87 | FGFR4 (0.45) | FGFR4RAF1GPR142PRMT5WDR77 | |
| SCHEMBL12959030 | 0.87 | FGFR4 (0.45) | FGFR4RAF1GPR142PRMT5WDR77 | |
| SCHEMBL12805950 | 0.87 | FGFR4 (0.45) | FGFR4RAF1GPR142PRMT5WDR77 | |
| SCHEMBL17655329 | 0.87 | FGFR4 (0.39) | FGFR4RAF1PRMT5WDR77CA2 | |
| SCHEMBL12653830 | 0.85 | RAF1 (0.35) | RAF1PRMT5WDR77BRAFCA2 | |
| SCHEMBL12654420 | 0.85 | RAF1 (0.35) | RAF1PRMT5WDR77CA2CA9 | |
| SCHEMBL12653828 | 0.85 | FGFR4 (0.45) | FGFR4RAF1GPR142PRMT5WDR77 | |
| SCHEMBL12653807 | 0.85 | RAF1 (0.36) | FGFR4RAF1CNR2 | |
| SCHEMBL16785536 | 0.85 | RAF1 (0.36) | RAF1PRMT5WDR77CA2CA9 | |
| SCHEMBL17655352 | 0.83 | FGFR4 (0.43) | FGFR4RAF1GPR142CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |