Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18415689 | 1.00 | FGFR4 (0.43) | FGFR4CA2CA9GPR142KMO | |
| SCHEMBL18415688 | 1.00 | FGFR4 (0.43) | FGFR4CA2CA9GPR142KMO | |
| SCHEMBL12805950 | 0.90 | FGFR4 (0.45) | FGFR4CA2CA9GPR142RAF1 | |
| SCHEMBL12959030 | 0.90 | FGFR4 (0.45) | FGFR4CA2CA9GPR142RAF1 | |
| SCHEMBL12805953 | 0.90 | FGFR4 (0.45) | FGFR4CA2CA9GPR142RAF1 | |
| SCHEMBL12653828 | 0.88 | FGFR4 (0.45) | FGFR4CA2CA9GPR142KMO | |
| SCHEMBL12654665 | 0.88 | PRMT5 (0.39) | FGFR4CA2CA9KMOPRMT5 | |
| SCHEMBL17655335 | 0.86 | FGFR4 (0.43) | FGFR4CA2CA9KMOPRMT5 | |
| SCHEMBL12654418 | 0.85 | CA2 (0.37) | FGFR4CA2CA9KMORAF1 | |
| SCHEMBL12654671 | 0.85 | GPR142 (0.33) | FGFR4GPR142KMORAF1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |