Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754337 | 0.78 | RAB9A (0.50) | NPC1RAB9ATP53SMN1; SMN2HSD17B10 | |
| SCHEMBL15742345 | 0.78 | NR1H4 (0.44) | NPC1RAB9ATSHRTP53SMN1; SMN2 | |
| SCHEMBL27564200 | 0.78 | GRM5 (0.40) | NOTUM | |
| SCHEMBL1186813 | 0.78 | ESR1 (0.42) | NPC1RAB9ATP53SMN1; SMN2HSD17B10 | |
| SCHEMBL17655984 | 0.76 | NOTUM (0.50) | NOTUMTP53MAOB | |
| SCHEMBL2670835 | 0.76 | TP53 (0.48) | NPC1RAB9ANOTUMTSHRTP53 | |
| SCHEMBL24921583 | 0.74 | NPC1 (0.49) | NPC1RAB9ANOTUMTP53SMN1; SMN2 | |
| SCHEMBL17656035 | 0.74 | NOTUM (0.49) | NPC1RAB9ANOTUMACHECASP3 | |
| SCHEMBL27612731 | 0.72 | — | — | |
| SCHEMBL27612967 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815206-B1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS INC (US) | 2016-04-06 | — | — | EP | disclosed |