Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBX7 | O95931 | 2/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL204238 | 0.87 | GSK3B (0.55) | CBX7CDYLCDY1; CDY1BTTRMAPT | |
| SCHEMBL13070481 | 0.82 | ATM (0.45) | STSTTRMAPTHTR2BSMN1; SMN2 | |
| SCHEMBL8954362 | 0.81 | TTR (0.57) | TTRHTR2BKDM4EALDH1A1HSD17B10 | |
| SCHEMBL13070610 | 0.81 | STS (0.39) | STSTTRMAPTHTR2BSMN1; SMN2 | |
| SCHEMBL19318868 | 0.80 | NPC1 (0.46) | TTRMAPTHTR2BSMN1; SMN2KDM4E | |
| SCHEMBL204756 | 0.78 | PTPN1 (0.50) | TTRMAPTHTR2BGSK3BSMN1; SMN2 | |
| SCHEMBL23693530 | 0.77 | TTR (0.53) | TTRMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL23693577 | 0.77 | TTR (0.56) | TTRMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29886929 | 0.77 | TTR (0.56) | TTRMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL203439 | 0.76 | MAPT (0.50) | MAPTSMN1; SMN2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-3002281-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2016-04-06 | — | — | EP | disclosed |