Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19339694 | 1.00 | ALDH1A1 (0.35) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL16001516 | 0.76 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL205306 | 0.71 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL19339371 | 0.67 | HDAC1 (0.33) | ALDH1A1GAASMN1; SMN2PTGFRMAPT | |
| SCHEMBL671822 | 0.62 | AKR1C1 (0.53) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL15513651 | 0.62 | ALDH1A1 (0.47) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL21200393 | 0.62 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL29575175 | 0.62 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL30016494 | 0.61 | PARP1 (0.47) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 | |
| SCHEMBL3926671 | 0.61 | PARP1 (0.47) | ALDH1A1GAASMN1; SMN2NPSR1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-3002281-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2016-04-06 | — | — | EP | disclosed |