Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 6/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13155045 | 0.81 | PDE10A (0.47) | PDE10ACCNCCDK8HRH3ADRA1A | |
| SCHEMBL13187459 | 0.80 | PDE10A (0.46) | PDE10AACACBCCNCCDK8HRH3 | |
| SCHEMBL22153203 | 0.80 | PDE10A (0.46) | PDE10ACCNCCDK8 | |
| SCHEMBL14992972 | 0.80 | ACACB (0.50) | PDE10AACACBCCNCCDK8HRH3 | |
| SCHEMBL2791709 | 0.80 | PDE10A (0.46) | PDE10AACACBCCNCCDK8HRH3 | |
| SCHEMBL26151683 | 0.78 | PDE10A (0.44) | PDE10AACACBCCNCCDK8HRH3 | |
| SCHEMBL13155029 | 0.78 | ACACB (0.56) | PDE10AACACBCCNCCDK8HRH3 | |
| SCHEMBL17619889 | 0.77 | GRM1 (0.41) | PDE10AMAP3K12 | |
| SCHEMBL19604785 | 0.77 | AOC3 (0.39) | ACACBMAP3K12 | |
| SCHEMBL24312834 | 0.77 | KDM4E (0.43) | ACACBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002278-B1 | GUANIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-04-19 | — | — | EP | disclosed |
| EP-2695881-B1 | GUANIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-27 | — | — | EP | disclosed |
| EP-3002278-A1 | GUANIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-06 | — | — | EP | disclosed |