Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.52 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223726 | 0.90 | CHRM1 (0.54) | ADAM17CHRM1 | |
| SCHEMBL6892258 | 0.87 | GAA (0.56) | GAAKMT2A | |
| SCHEMBL17656772 | 0.83 | ADAM17 (0.47) | ADAM17SSTR3CHRM1MMP3MMP7 | |
| SCHEMBL2224663 | 0.81 | CHRM1 (0.69) | ADAM17CHRM1MMP3MMP7MMP10 | |
| SCHEMBL6892534 | 0.81 | CHRM1 (0.69) | ADAM17CHRM1MMP3MMP7MMP10 | |
| SCHEMBL2224665 | 0.81 | CHRM1 (0.69) | ADAM17CHRM1MMP3MMP7MMP10 | |
| SCHEMBL2221937 | 0.79 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL12803258 | 0.79 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL6891025 | 0.79 | CHRM1 (0.70) | CHRM1 | |
| SCHEMBL12802941 | 0.79 | CHRM1 (0.70) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |