Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | CDK11B | P21127 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.38 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627855 | 0.92 | GSK3B (0.51) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL12336259 | 0.84 | GSK3B (0.45) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL17658738 | 0.83 | GSK3B (0.39) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL12336275 | 0.83 | KDR (0.51) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL626404 | 0.82 | PDGFRB (0.65) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL12336297 | 0.82 | KDR (0.59) | GSK3BPDGFRBKITPDGFRACDK11B | |
| SCHEMBL3531460 | 0.79 | GSK3B (0.46) | GSK3BMEN1NPC1TP53MAPK1 | |
| SCHEMBL12057527 | 0.79 | NPC1 (0.47) | GSK3BKDRFLT1MEN1NPC1 | |
| SCHEMBL12336240 | 0.78 | GSK3B (0.60) | GSK3BKDRFLT1BRAFMAPK14 | |
| SCHEMBL12336253 | 0.77 | GSK3B (0.51) | GSK3BKDRFLT1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160096824-A1 | Heterocyclic Compounds Useful for Kinase Inhibition | AMITECH THERAPEUTIC SOLUTIONS, INC. | 2016-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096824-A1 | Heterocyclic Compounds Useful for Kinase Inhibition | MAP4K2, MAP3K20, MAP3K19 | GSK3B 581/4885PDGFRB 497/4885KIT 540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.