Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 19/20 | 0.61 |
| ▸ | TDO2 | P48775 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135356 | 1.00 | IDO1 (0.61) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL17665329 | 1.00 | IDO1 (0.61) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL17665332 | 1.00 | IDO1 (0.61) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL17665330 | 1.00 | IDO1 (0.61) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL16135397 | 0.99 | IDO1 (0.60) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL16135347 | 0.89 | TDO2 (0.55) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL16135374 | 0.87 | TDO2 (0.53) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL17665472 | 0.87 | IDO1 (0.47) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL16135337 | 0.85 | TDO2 (0.51) | IDO1TDO2CYP3A4CYP2D6CYP2B6 | |
| SCHEMBL16135345 | 0.84 | TDO2 (0.52) | IDO1TDO2CYP3A4CYP2D6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |