Acetophenone-Thiosemicarbazone

Acetophenone-Thiosemicarbazone

SCHEMBL17666972

C/C(=N/NC(N)=S)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
METTL3 Q86U44 2/20 1.00
ATM Q13315 1/20 1.00
CTSK P43235 1/20 0.73
ALDH1A1 P00352 1/20 0.68
LMNA P02545 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenyl(Methyl)Thiosemicarbazone SCHEMBL757506 1.00 METTL3 (1.00) METTL3ATMCTSKALDH1A1LMNA
Phenyl(Methyl)Thiosemicarbazone SCHEMBL14436799 1.00 METTL3 (1.00) METTL3ATMCTSKALDH1A1LMNA
Phenyl(Methyl)Thiosemicarbazone SCHEMBL27879446 0.95 METTL3 (0.90) METTL3ATMCTSKALDH1A1LMNA
SCHEMBL23794042 0.90 METTL3 (0.82) METTL3ATMCTSK
SCHEMBL4332229 0.90 METTL3 (0.81) METTL3ATMCTSK
SCHEMBL4332234 0.90 METTL3 (0.81) METTL3ATMCTSK
SCHEMBL5525649 0.87 METTL3 (0.76) METTL3ATMCTSK
SCHEMBL5525645 0.87 METTL3 (0.76) METTL3ATMCTSK
SCHEMBL5526650 0.85 ATM (0.73) METTL3ATMCTSKALDH1A1
SCHEMBL5531907 0.85 METTL3 (0.73) METTL3ATMCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006496-B1 TIRE RUBBER COMPOSITION AND MANUFACTURING METHOD THEREFOR BRIDGESTONE CORP (JP) 2017-07-19 EP claimed
EP-3006496-B1 TIRE RUBBER COMPOSITION AND MANUFACTURING METHOD THEREFOR BRIDGESTONE CORP (JP) 2017-07-19 EP disclosed
US-20160115296-A1 TIRE RUBBER COMPOSITION AND MANUFACTURING METHOD THEREFOR BRIDGESTONE CORPORATION (JP) 2016-04-28 US disclosed
EP-3006496-A1 TIRE RUBBER COMPOSITION AND MANUFACTURING METHOD THEREFOR Bridgestone Corporation (JP) 2016-04-13 EP disclosed