Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17667297 | 1.00 | PRKDC (0.40) | PRKDCRORCHRH4JAK2JAK3 | |
| SCHEMBL17628237 | 0.81 | OPRM1 (0.46) | PRKDCHRH4JAK2JAK3PDE10A | |
| SCHEMBL17667319 | 0.81 | JAK2 (0.39) | RORCHRH4JAK2JAK3CNR2 | |
| SCHEMBL17628165 | 0.77 | JAK2 (0.39) | RORCHRH4JAK2JAK3PDE10A | |
| SCHEMBL17628378 | 0.77 | PRKDC (0.44) | PRKDCCNR2PDE10AKMT2APIK3CA | |
| SCHEMBL15929081 | 0.77 | EIF2AK4 (0.42) | HRH4TRPV1 | |
| SCHEMBL17667317 | 0.77 | PDE10A (0.56) | PRKDCJAK2JAK3CNR2PDE10A | |
| SCHEMBL17628072 | 0.77 | CNR2 (0.47) | PRKDCCNR2PDE10AKMT2APIK3CD | |
| SCHEMBL17628070 | 0.77 | CNR2 (0.47) | PRKDCCNR2PDE10AKMT2APIK3CD | |
| SCHEMBL17667365 | 0.75 | HRH4 (0.36) | PRKDCHRH4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |