Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | GSK3A | P49840 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 7/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17667701 | 0.92 | PLK4 (0.37) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667678 | 0.90 | PRKCZ (0.42) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667685 | 0.90 | ALK (0.38) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667698 | 0.88 | GSK3B (0.36) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667691 | 0.88 | GSK3B (0.36) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667692 | 0.87 | SGK1 (0.41) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667690 | 0.87 | SMYD3 (0.42) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667674 | 0.87 | SMYD3 (0.42) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667681 | 0.86 | SGK1 (0.36) | GSK3BGSK3ACDK2PIM1PIK3CD | |
| SCHEMBL17667686 | 0.86 | MAPK1 (0.34) | GSK3BGSK3ACDK2PIM1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771340-B1 | 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS | SANOFI SA (FR) | 2016-04-13 | — | — | EP | claimed |