Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.75 |
| ▸ | RECQL | P46063 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17668974 | 1.00 | NPC1 (0.75) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL13435257 | 0.92 | NPC1 (0.89) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL13531827 | 0.92 | NPC1 (0.89) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL29960037 | 0.90 | RAB9A (0.79) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL1538505 | 0.90 | RAB9A (0.79) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL27766600 | 0.88 | RAB9A (0.65) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL9187561 | 0.87 | NPC1 (1.00) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL17669085 | 0.86 | NPC1 (0.63) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL7343243 | 0.85 | NPC1 (0.77) | NPC1RAB9ARECQLALDH1A1LMNA | |
| SCHEMBL23221367 | 0.84 | NPC1 (0.75) | NPC1RAB9ARECQLALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108527-B | Ataxia telangiectasia and Rad 3-Associated (ATR) protein kinase inhibitors | 阿特林制药有限责任公司 | 2022-08-02 | — | — | CN | disclosed |
| EP-3207031-B1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2021-04-14 | — | — | EP | disclosed |
| EP-3207031-B1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10196405-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2019-02-05 | — | — | US | disclosed |
| US-10196405-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2019-02-05 | — | — | US | disclosed |
| US-9981989-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981989-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981989-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2018-05-29 | — | — | US | disclosed |
| EP-3207031-A1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-08-10 | — | — | US | disclosed |
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-08-10 | — | — | US | disclosed |
| US-9663535-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663535-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663535-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | Atrin Pharmaceuticals LLC (US) | 2017-05-30 | — | — | US | disclosed |
| WO-2016061097-A1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2016-04-21 | — | — | WO | disclosed |
| WO-2016061097-A1 | ATAXIA TELENGIECTASIA AND RAD3-RELATED (ATR) PROTEIN KINASE INHIBITORS | Atrin Pharmaceuticals LLC (US) | 2016-04-21 | — | — | WO | disclosed |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2016-04-14 | — | — | US | disclosed |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | Atrin Pharmaceuticals LLC (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226130-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | CHEK2, ATR, CHEK1 | NPC1 4190/4885RAB9A 1054/4885RECQL 20/4885 |
| US-20160102104-A1 | Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors | ATR, CHEK1, CHEK2 | NPC1 4772/4885RAB9A 1829/4885RECQL 84/4885 |
| US-10196405-B2 | Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors | CHEK2, ATR, CHEK1 | NPC1 4202/4885RAB9A 1049/4885RECQL 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.