Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 20/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17669188 | 1.00 | PCSK9 (0.60) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17669187 | 0.96 | PCSK9 (0.65) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17669176 | 0.94 | PCSK9 (0.56) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17669170 | 0.94 | PCSK9 (0.56) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17669168 | 0.94 | PCSK9 (0.56) | PCSK9KCNH2CHRM1PDE4D | |
| Hydrochloric Acid SCHEMBL17669179 | 0.93 | PCSK9 (0.56) | PCSK9KCNH2CHRM1PDE4D | |
| Hydrochloric Acid SCHEMBL17669180 | 0.93 | PCSK9 (0.56) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17679150 | 0.93 | PCSK9 (0.63) | PCSK9KCNH2CHRM1PDE4D | |
| SCHEMBL17669177 | 0.91 | PCSK9 (0.71) | PCSK9KCNH2 | |
| SCHEMBL16179907 | 0.91 | PCSK9 (0.71) | PCSK9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055901-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | WO | claimed |
| WO-2016055901-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | PFIZER INC. (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102074-A1 | SUBSTITUTED AMIDE COMPOUNDS | CETP, APOB, LCAT | PCSK9 35/4885KCNH2 4672/4885CHRM1 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.