Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLI1 | Q01543 | 6/20 | 0.65 |
| ▸ | EWSR1 | Q01844 | 6/20 | 0.65 |
| ▸ | ERG | P11308 | 1/20 | 0.65 |
| ▸ | ETV1 | P50549 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 6/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | CBX7 | O95931 | 2/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.41 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17679860 | 1.00 | FLI1 (0.65) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL29810798 | 1.00 | FLI1 (0.65) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL17679859 | 1.00 | FLI1 (0.65) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL17679867 | 0.91 | KMT2A (0.71) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL13253330 | 0.87 | FLI1 (0.71) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL17679832 | 0.87 | FLI1 (0.58) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL17679824 | 0.87 | FLI1 (0.58) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL29810801 | 0.87 | FLI1 (0.58) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL17669258 | 0.87 | FLI1 (0.58) | FLI1EWSR1ERGETV1KMT2A | |
| SCHEMBL13253325 | 0.86 | KMT2A (0.84) | FLI1EWSR1ERGETV1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076941-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | UNIV GEORGETOWN (US) | 2026-03-19 | — | — | US | disclosed |
| EP-3204376-B1 | INDOLINONE COMPOUNDS AND USES THEREOF | ONCTERNAL THERAPEUTICS INC (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-3204376-B1 | INDOLINONE COMPOUNDS AND USES THEREOF | ONCTERNAL THERAPEUTICS INC (US) | 2023-04-19 | — | — | EP | disclosed |
| US-20220288023-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2022-09-15 | — | — | US | disclosed |
| CN-111777596-A | Indolone compounds and use thereof | 英克特诺治疗公司 | 2020-10-16 | — | — | CN | disclosed |
| US-20200253927-A1 | USES OF INDOLINONE COMPOUNDS | GEORGETOWN UNIVERSITY | 2020-08-13 | — | — | US | disclosed |
| CN-107108580-B | Indolone compounds and use thereof | 英克特诺治疗公司 | 2020-06-30 | — | — | CN | disclosed |
| US-10646470-B2 | Uses of indolinone compounds | Oncternal Therapeutics, Inc. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190022062-A1 | USES OF INDOLINONE COMPOUNDS | GEORGETOWN UNIVERSITY | 2019-01-24 | — | — | US | disclosed |
| US-20180256546-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2018-09-13 | — | — | US | disclosed |
| US-20170065559-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-20170066720-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-20170065559-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-20170066720-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| US-20170066720-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2017-03-09 | — | — | US | disclosed |
| WO-2016057698-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | Tokalas, Inc. (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016057698-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | Tokalas, Inc. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20160102055-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| US-20160102055-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
| US-20160102055-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | GEORGETOWN UNIVERSITY | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253927-A1 | USES OF INDOLINONE COMPOUNDS | MCL1, BCL3, BCL9 | FLI1 8/4885EWSR1 823/4885ERG 311/4885 |
| US-20170066720-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, IKZF1 | FLI1 1/4885EWSR1 2/4885ERG 4/4885 |
| US-20160102055-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, IKZF1 | FLI1 1/4885EWSR1 2/4885ERG 4/4885 |
| US-20260076941-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, HNRNPH3 | FLI1 1/4885EWSR1 2/4885ERG 10/4885 |
| US-10646470-B2 | Uses of indolinone compounds | MCL1, BCL3, BCL9 | FLI1 8/4885EWSR1 823/4885ERG 311/4885 |
| US-20220288023-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, IKZF1 | FLI1 1/4885EWSR1 2/4885ERG 4/4885 |
| US-20170065559-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, IKZF1 | FLI1 1/4885EWSR1 2/4885ERG 4/4885 |
| US-20180256546-A1 | INDOLINONE COMPOUNDS AND USES THEREOF | FLI1, EWSR1, IKZF1 | FLI1 1/4885EWSR1 2/4885ERG 4/4885 |
| US-20190022062-A1 | USES OF INDOLINONE COMPOUNDS | MCL1, BCL3, BCL9 | FLI1 8/4885EWSR1 823/4885ERG 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.