Sugi Predict

Sugi Predict / Compounds / SCHEMBL17679867

SCHEMBL17679867

SCHEMBL17679867

Cc1ccc(C(=O)CC2(O)C(=O)Nc3c(Cl)ccc(Cl)c32)cc1F

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.71
▸ MEN1 O00255 1/20 0.71
▸ ALDH1A1 P00352 6/20 0.65
▸ HTT P42858 1/20 0.65
▸ NPSR1 Q6W5P4 1/20 0.65
▸ FLI1 Q01543 6/20 0.63
▸ EWSR1 Q01844 6/20 0.63
▸ ERG P11308 1/20 0.63
▸ ETV1 P50549 1/20 0.63
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ TP53 P04637 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ MMP2 P08253 4/20 0.41
▸ MMP8 P22894 4/20 0.41
▸ MMP9 P14780 3/20 0.41
▸ ALOX12 P18054 1/20 0.38
▸ HDAC1 Q13547 1/20 0.38
▸ HDAC6 Q9UBN7 1/20 0.38
▸ CBX7 O95931 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17669259 0.91 FLI1 (0.65) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL17679859 0.91 FLI1 (0.65) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL29810798 0.91 FLI1 (0.65) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL17679860 0.91 FLI1 (0.65) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL13253330 0.85 FLI1 (0.71) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL17679824 0.84 FLI1 (0.58) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL17679832 0.84 FLI1 (0.58) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL29810801 0.84 FLI1 (0.58) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL17669258 0.84 FLI1 (0.58) KMT2AMEN1ALDH1A1HTTNPSR1
SCHEMBL13253325 0.84 KMT2A (0.84) KMT2AMEN1ALDH1A1HTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9987251-B2 Indolinone compounds and uses thereof Oncternal Therapeutics, Inc. (US) 2018-06-05 — — US disclosed
US-9895352-B2 Indolinone compounds and uses thereof Oncternal Therapeutics, Inc. (US) 2018-02-20 — — US disclosed
US-20180028495-A1 USES OF INDOLINONE COMPOUNDS GEORGETOWN UNIVERSITY 2018-02-01 — — US disclosed
US-20170066720-A1 INDOLINONE COMPOUNDS AND USES THEREOF GEORGETOWN UNIVERSITY 2017-03-09 — — US disclosed
US-20170065559-A1 INDOLINONE COMPOUNDS AND USES THEREOF GEORGETOWN UNIVERSITY 2017-03-09 — — US disclosed
US-20160102055-A1 INDOLINONE COMPOUNDS AND USES THEREOF GEORGETOWN UNIVERSITY 2016-04-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180028495-A1 USES OF INDOLINONE COMPOUNDS MCL1, BCL3, BCL9 KMT2A 1127/4885MEN1 1770/4885ALDH1A1 2264/4885
US-20170066720-A1 INDOLINONE COMPOUNDS AND USES THEREOF FLI1, EWSR1, IKZF1 KMT2A 1097/4885MEN1 2529/4885ALDH1A1 1699/4885
US-20160102055-A1 INDOLINONE COMPOUNDS AND USES THEREOF FLI1, EWSR1, IKZF1 KMT2A 1097/4885MEN1 2529/4885ALDH1A1 1699/4885
US-20170065559-A1 INDOLINONE COMPOUNDS AND USES THEREOF FLI1, EWSR1, IKZF1 KMT2A 1097/4885MEN1 2529/4885ALDH1A1 1699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.