Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17673778 | 0.89 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL17673786 | 0.87 | PIK3CA (0.49) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL17673620 | 0.87 | MAPT (0.46) | MAPK10PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL17677913 | 0.86 | PIK3CA (0.55) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL17673766 | 0.86 | PIK3CA (0.46) | MAPK8MAPK10PIK3CAPIK3CGPIK3CD | |
| SCHEMBL17677939 | 0.86 | MAPT (0.47) | MAPK8MAPK10PIK3CAPIK3CGPIK3CD | |
| SCHEMBL17673781 | 0.85 | MAPK10 (0.47) | MAPK8MAPK10PIK3CAPIK3CGPIK3CD | |
| SCHEMBL17673682 | 0.85 | PIK3CA (0.50) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL17673842 | 0.85 | LMNA (0.59) | PIK3CAPIK3CGPIK3CDPIK3CBMTOR | |
| SCHEMBL17673877 | 0.85 | MAPK10 (0.50) | MAPK8MAPK10PIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204009-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057834-A9 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2017-04-13 | — | — | WO | disclosed |
| WO-2016057834-A1 | HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2016-04-14 | — | — | WO | disclosed |