Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674281 | 0.94 | NTRK1 (0.55) | NTRK1NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674320 | 0.93 | NTRK1 (0.56) | NTRK1NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674248 | 0.90 | NTRK1 (0.55) | NTRK1NTRK3 | |
| SCHEMBL17674418 | 0.88 | NTRK1 (0.53) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674428 | 0.86 | NTRK1 (0.56) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674315 | 0.86 | NTRK1 (0.58) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674425 | 0.84 | NTRK1 (0.53) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674302 | 0.82 | NTRK1 (0.52) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17674408 | 0.81 | NTRK1 (0.69) | NTRK1PTGS2NTRK3LMNASMN1; SMN2 | |
| SCHEMBL17680281 | 0.81 | NTRK1 (0.55) | NTRK1NTRK3LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | claimed |
| WO-2016054807-A1 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | WO | disclosed |