Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675515 | 0.90 | BTK (0.49) | MAPTBTKEGFRKDRPDGFRA | |
| SCHEMBL17675318 | 0.84 | BTK (0.66) | MAPTRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL17675295 | 0.83 | KDR (0.48) | MAPTBTKEGFRKDRPDGFRA | |
| SCHEMBL17675511 | 0.82 | KMT2A (0.55) | MAPTRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL17675493 | 0.80 | BTK (0.68) | MAPTRAB9ANPC1SMN1; SMN2BTK | |
| SCHEMBL17675293 | 0.78 | EGFR (0.49) | MAPTRAB9ABTKEGFRKDR | |
| SCHEMBL17675471 | 0.76 | BTK (0.52) | RAB9ANPC1ALDH1A1SMN1; SMN2BTK | |
| SCHEMBL17675216 | 0.75 | BTK (0.54) | MAPTBTKEGFRKDRPTGS1 | |
| SCHEMBL30354762 | 0.75 | MAPT (0.77) | MAPTRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL13428702 | 0.75 | MAPT (0.77) | MAPTRAB9ANPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |