Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675515 | 0.88 | BTK (0.49) | EGFRBTKKDRBRAFMAPK14 | |
| SCHEMBL17675462 | 0.86 | BTK (0.51) | EGFRBTKKDRBRAFMAPK14 | |
| SCHEMBL17675311 | 0.85 | BTK (0.66) | EGFRBTKKDRUSP2MAPT | |
| SCHEMBL17675170 | 0.84 | EGFR (0.53) | EGFRBTKKDRUSP2MAPT | |
| SCHEMBL17675352 | 0.81 | EGFR (0.74) | EGFRBTKKDRBRAFMAPK14 | |
| SCHEMBL28954009 | 0.81 | MAPT (0.53) | BTKGRM5MAPTKMT2ARAB9A | |
| SCHEMBL17675433 | 0.79 | KDR (0.59) | KDRBRAFMAPK14TNNI3KGRM5 | |
| SCHEMBL17675288 | 0.78 | MAPT (0.48) | EGFRBTKKDRBRAFMAPK14 | |
| SCHEMBL13428725 | 0.76 | STAT3 (0.53) | MAPTKMT2ARAB9A | |
| SCHEMBL17683822 | 0.75 | EGFR (0.72) | EGFRBTKKDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |