Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.70 |
| ▸ | EGFR | P00533 | 6/20 | 0.70 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683820 | 0.85 | BTK (0.77) | BTKEGFRCSF1RF2NPC1 | |
| SCHEMBL17675235 | 0.84 | BTK (0.73) | BTKEGFRF2NPC1RAB9A | |
| SCHEMBL17675311 | 0.84 | BTK (0.66) | BTKEGFRF2NPC1RAB9A | |
| SCHEMBL17675208 | 0.84 | BTK (0.56) | BTKEGFRCSF1RNPC1RAB9A | |
| SCHEMBL17675462 | 0.84 | BTK (0.51) | BTKEGFRCSF1RKDR | |
| SCHEMBL17675474 | 0.84 | BTK (0.60) | BTKEGFRCSF1RF2KDR | |
| SCHEMBL17675434 | 0.83 | EGFR (1.00) | BTKEGFRF2CHRNB2CHRNB4 | |
| SCHEMBL17675188 | 0.81 | EGFR (0.74) | BTKEGFRNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL17675534 | 0.80 | BTK (0.69) | BTKEGFRCSF1RF2KDR | |
| SCHEMBL17683840 | 0.79 | BTK (0.79) | BTKEGFRCSF1RF2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |