Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | NEK4 | P51957 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675216 | 0.87 | BTK (0.54) | BTKEGFRKDRBRAFMAPK14 | |
| SCHEMBL17675293 | 0.86 | EGFR (0.49) | BTKEGFRKDRBRAFMAPK14 | |
| SCHEMBL17675433 | 0.85 | KDR (0.59) | KDRBRAFMAPK14TNNI3KGRM5 | |
| SCHEMBL17675352 | 0.84 | EGFR (0.74) | BTKEGFRKDRBRAFMAPK14 | |
| SCHEMBL17675332 | 0.84 | BTK (0.70) | BTKEGFRKDRCSF1R | |
| SCHEMBL17675208 | 0.83 | BTK (0.56) | BTKEGFRKDRFLT3CSF1R | |
| SCHEMBL17683706 | 0.81 | BTK (0.59) | BTKEGFRKDRBRAFMAPK14 | |
| SCHEMBL17683762 | 0.80 | BTK (0.62) | BTKEGFRKDRBRAFMAPK14 | |
| SCHEMBL28953974 | 0.79 | PTGS1 (0.67) | BTKEGFRGRM5PTGS1 | |
| SCHEMBL17683793 | 0.79 | KDR (0.54) | BTKEGFRKDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |