Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675602 | 0.89 | BTK (0.76) | BTKAURKBAURKAEGFRKDR | |
| SCHEMBL17675257 | 0.87 | EGFR (0.72) | BTKAURKBAURKAEGFRKDR | |
| SCHEMBL17675217 | 0.86 | KDR (0.63) | BTKAURKBAURKAEGFRKDR | |
| SCHEMBL17683840 | 0.86 | BTK (0.79) | BTKEGFRKDRERBB4ERBB2 | |
| SCHEMBL17683823 | 0.85 | EGFR (0.72) | BTKAURKBAURKAEGFRERBB4 | |
| SCHEMBL17683789 | 0.82 | BTK (1.00) | BTKEGFRKDRERBB4ERBB2 | |
| SCHEMBL17675298 | 0.78 | EGFR (0.67) | BTKEGFRERBB4ERBB2MAPK14 | |
| SCHEMBL17675224 | 0.78 | EGFR (0.70) | BTKAURKBAURKAEGFRERBB4 | |
| SCHEMBL17675188 | 0.77 | EGFR (0.74) | BTKAURKBAURKAEGFRERBB2 | |
| SCHEMBL8933899 | 0.76 | AURKB (0.94) | AURKBAURKAEGFRKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |