Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 11/20 | 0.76 |
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | TEC | P42680 | 2/20 | 0.55 |
| ▸ | TXK | P42681 | 2/20 | 0.55 |
| ▸ | BLK | P51451 | 2/20 | 0.55 |
| ▸ | BMX | P51813 | 2/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.47 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675397 | 0.89 | BTK (0.70) | BTKEGFRERBB4ERBB2AURKA | |
| SCHEMBL17683789 | 0.86 | BTK (1.00) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675184 | 0.86 | BTK (0.73) | BTKEGFRDNMT1DNMT3LDNMT3A | |
| SCHEMBL17683840 | 0.82 | BTK (0.79) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675586 | 0.79 | EGFR (0.62) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675255 | 0.79 | BTK (0.85) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675187 | 0.78 | DNMT1 (0.66) | BTKEGFRDNMT1DNMT3LDNMT3A | |
| SCHEMBL17675217 | 0.78 | KDR (0.63) | BTKEGFRERBB2AURKAAURKB | |
| SCHEMBL17675558 | 0.77 | BTK (0.82) | BTKEGFRTECTXKBLK | |
| SCHEMBL17683763 | 0.77 | BTK (1.00) | BTKEGFRTECTXKBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |