Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
| ▸ | MERTK | Q12866 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | TXK | P42681 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675242 | 0.87 | BTK (0.68) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675295 | 0.86 | KDR (0.48) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675241 | 0.85 | EGFR (0.67) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675216 | 0.83 | BTK (0.54) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675609 | 0.80 | BTK (0.70) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675235 | 0.79 | BTK (0.73) | BTKEGFRKDRERBB2TEC | |
| SCHEMBL17675438 | 0.78 | BTK (0.59) | BTKEGFRERBB2TECTXK | |
| SCHEMBL17675491 | 0.76 | KDM4E (0.54) | PIK3CA | |
| SCHEMBL17675289 | 0.76 | BTK (0.72) | BTKEGFRMETAXLMERTK | |
| SCHEMBL17675229 | 0.74 | BTK (0.62) | BTKEGFRMETAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |