Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.57 |
| ▸ | EGFR | P00533 | 10/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | TEC | P42680 | 2/20 | 0.48 |
| ▸ | TXK | P42681 | 2/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.48 |
| ▸ | BMX | P51813 | 2/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675210 | 0.91 | BTK (0.67) | BTKEGFRKDRPDGFRACYP3A4 | |
| SCHEMBL17675478 | 0.87 | BTK (0.60) | BTKEGFRKDRPDGFRACYP3A4 | |
| SCHEMBL17675365 | 0.87 | BTK (0.59) | BTKEGFRKDRPDGFRACYP3A4 | |
| SCHEMBL17675573 | 0.86 | BTK (0.55) | BTKEGFRKDRPDGFRACYP3A4 | |
| SCHEMBL17675309 | 0.82 | BTK (0.65) | BTKEGFRKDRPDGFRACYP3A4 | |
| SCHEMBL17675543 | 0.82 | BTK (0.62) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675318 | 0.81 | BTK (0.66) | BTKEGFRKDRPDGFRATEC | |
| SCHEMBL17675287 | 0.81 | BTK (0.61) | BTKEGFRTECTXKBLK | |
| SCHEMBL17675464 | 0.80 | BTK (0.71) | BTKEGFRKDRTECTXK | |
| SCHEMBL17675436 | 0.79 | BTK (0.57) | BTKEGFRKDRPDGFRAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |