Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azeliragon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER known ✓ | Q15109 | 14/20 | 0.91 |
| ▸ | ATP4A | P20648 | 1/20 | 0.46 |
| ▸ | ATP4B | P51164 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1283514 | 0.96 | AGER (1.00) | AGERATP4AATP4BHRH3 | |
| Azeliragon SCHEMBL1142599 | 0.96 | AGER (1.00) | AGERATP4AATP4BHRH3 | |
| Azeliragon SCHEMBL1893545 | 0.95 | AGER (0.98) | AGERATP4AATP4BHRH3 | |
| SCHEMBL23631278 | 0.91 | AGER (1.00) | AGER | |
| SCHEMBL1283711 | 0.89 | AGER (0.86) | AGERATP4AATP4BHRH3 | |
| SCHEMBL3508025 | 0.88 | AGER (0.86) | AGERATP4AATP4BHRH3 | |
| SCHEMBL18650027 | 0.88 | AGER (0.86) | AGERATP4AATP4BHRH3 | |
| SCHEMBL1283435 | 0.87 | AGER (0.84) | AGERATP4AATP4BHRH3 | |
| SCHEMBL1283367 | 0.87 | AGER (0.84) | AGERATP4AATP4BHRH3 | |
| SCHEMBL1284076 | 0.87 | AGER (0.86) | AGERHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324830-A1 | Process for the preparation of a monocyclic azole derivative that inhibits the interaction of ligands with rage | TransTech Pharma Inc. (US) | 2011-05-25 | — | — | EP | disclosed |