Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608620 | 0.85 | HDAC6 (0.52) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30696707 | 0.81 | HDAC8 (0.53) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL30696587 | 0.79 | HDAC6 (0.46) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1608589 | 0.77 | HDAC6 (0.56) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1607765 | 0.77 | HDAC1 (0.51) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1608423 | 0.77 | HDAC8 (0.53) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL27339579 | 0.76 | ACHE (0.43) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1607594 | 0.75 | HDAC6 (0.50) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1608757 | 0.75 | KDM4E (0.49) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL1608311 | 0.75 | HDAC6 (0.60) | HDAC6HDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265590-B1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC (US) | 2016-04-13 | — | — | EP | disclosed |