Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | GLA | P06280 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31539359 | 0.79 | IDO1 (0.44) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL961786 | 0.77 | KDM4E (0.50) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL18608719 | 0.76 | KDM4E (0.59) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL7224845 | 0.76 | KDM4E (0.49) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL6215635 | 0.75 | KDM4E (0.48) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL6558246 | 0.75 | KDM4E (0.48) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL24170383 | 0.74 | KDM4E (0.53) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL23146843 | 0.74 | POLB (0.52) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL17464943 | 0.73 | P2RX3 (0.58) | KDM4EALDH1A1LMNAMAPTHTT | |
| SCHEMBL22932832 | 0.72 | KDM4E (0.51) | KDM4EHPGDALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3006438-A1 | CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2016-04-13 | — | — | EP | disclosed |