Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17677350 | 0.92 | KMT2A (0.43) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL13708879 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1062332 | 0.79 | SMO (0.48) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL13708845 | 0.78 | KMT2A (0.41) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL13708874 | 0.76 | LMNA (0.46) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1061898 | 0.76 | KMT2A (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL10314554 | 0.75 | SMO (0.42) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL10314630 | 0.71 | LMNA (0.45) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1056894 | 0.71 | SMO (0.55) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL1063259 | 0.70 | MEN1 (0.43) | MEN1KMT2AALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-B1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-04-13 | — | — | EP | disclosed |